ADXN Reports Q1 2026 Results

Addex Therapeutics (NASDAQ: ADXN ) reported first-quarter financial results on Thursday.

The transcript from the company's first-quarter earnings call has been provided below.

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The full earnings call is available at Summary Addex Therapeutics reported significant progress in its GABAB Positive Modulator Cough program, with preclinical data showing strong antitussive activity in non-human primates and guinea pigs.

The company is preparing Diproglurant for clinical studies in post-stroke recovery patients, with recent repositioning efforts and collaborations enhancing its development.

The financial report showed an operating loss of 0.5 million Swiss francs for Q1 2026, a decrease from the previous year due to reduced outsourced R&D.

Cash on hand was 0.9 million, providing a runway into Q4 2026, but not enough for unpartnered programs.

Addex retains a 20% equity interest in Neurosterix, which has advanced its M4PAM program into Phase 1, though this value is not reflected in Addex's current share price.

The company is in discussions to secure funding for its independent GABAB program for cough and has potential milestone payments of up to 330 million in its collaboration with Indivior for substance use disorders.

Full Transcript OPERATOR Good day and thank you for standing by.

Welcome to the Addex Therapeutics first quarter 2026 financial results and Corporate Update Conference Call and Webcast.

At this time, all participants are in listen-only mode.

After the speaker's presentation, there will be a question and answer session.

To ask a question during the session, you need to press Star 11 on your telephone keypad.

You will then hear an automatic message advising your hand is raised.

To withdraw a question, please press Star 11 again.

If you wish to ask a question via the webcast, please use the Q and A box available on the webcast link at any time during the live event.

Please be advised that today's conference is being recorded.

I would now like to hand the conference over to our first speaker today, Tim Dyer, CEO.

Please go ahead.

Tim Dyer, Chief Executive Officer Hello everyone.

I would like to thank you all for attending our Q1 2026 financial results conference call.

I am here with Mikhail Kalinichev, our Head of Translational Science, who will provide an update on our R&D program.

I draw your attention to the press release and the financial statements issued earlier today, which are available on our website.

I also draw your attention to our disclaimer.

We will be making certain forward-looking statements that are based on the knowledge we have today.

I will start this conference call by giving a quick overview of our recent activities and achievements before reviewing our pipeline.

I will then hand over to Misha, who will review in more detail our MGLUR5 negative allosteric modulator program for brain injury recovery and the GABAB Positive Modulator program for cough.

I will then review our 2026 Q1 financial results.

Following that, we will open the call for Q&A.

So starting with the highlights, Q1 has seen several important achievements across our pipeline.

We have made excellent progress in our GABAB Positive Modulator Cough program as we continue to complete preclinical characterization of our selective compound.

We recently announced robust antitussive activity in a non-human primate cough model as well as solid antitussive activity in an idiopathic pulmonary fibrosis model in guinea pigs.

These data further demonstrate the potential of our selected compound in this important unmet medical need.

In parallel to completing the preclinical profiling, we are working to secure funding to advance the program into the IND enabling studies.