INVO Fertility reports five PRP study abstracts at symposium

AGE AND OVARIAN RESERVE INFLUENCE RESPONSE TO OVARIAN PLATELET-RICH PLASMA IN IVF CYCLES KEY FINDINGS AND CONCLUSIONS: Among 19 patients, those younger than 35 years (n = 3) demonstrated the most robust improvements in ovarian response, including higher oocyte yield and improved embryo development.

Patients ages 35-39 (n = 9) showed moderate but generally consistent improvements, while patients age 40 and older (n = 7) experienced more limited responses and continued to demonstrate high rates of aneuploidy.

The abstract concludes that response to ovarian PRP appears to be influenced by age and underlying ovarian reserve; while ovarian responsiveness may improve across age groups, embryo competence remains largely age-dependent, highlighting the importance of patient selection.

OVARIAN PLATELET-RICH PLASMA IS ASSOCIATED WITH DE NOVO EUPLOID EMBRYO DEVELOPMENT AND SPONTANEOUS CONCEPTION IN PATIENTS WITH PRIOR POOR IVF OUTCOMES KEY FINDINGS AND CONCLUSIONS: In a 19-patient analysis in which each patient served as her own control, the study reported an overall increase in high-quality blastocyst development following PRP.

Two patients moved from producing no euploid embryos to producing multiple euploid embryos in subsequent cycles, and two patients conceived spontaneously while preparing for additional IVF treatment.

Patients of advanced maternal age continued to demonstrate high aneuploidy rates.

The abstract concludes that ovarian PRP may be associated with improved embryo competence and euploid embryo development in select patients with prior poor IVF outcomes and that the observations warrant further prospective investigation.

OVARIAN PLATELET-RICH PLASMA CONVERTS PREVIOUSLY NONPRODUCTIVE OR CANCELLED IVF CYCLES INTO VIABLE RETRIEVALS IN POOR RESPONDERS KEY FINDINGS AND CONCLUSIONS: Among 17 evaluable patients, baseline antral follicle count increased in 9, oocyte yield increased in 11, and mature oocyte counts increased in 10 following PRP.

Three patients with prior cycle cancellation or extremely poor response were able to proceed to oocyte retrieval, and 3 of 5 patients who had previously produced no embryos demonstrated embryo development in subsequent cycles.

The abstract concludes that ovarian PRP may enhance ovarian responsiveness and facilitate retrieval in patients with prior poor response or cancelled cycles, potentially offering an adjunctive option for a population with otherwise limited treatment success.

SUBENDOMETRIAL PLATELET-RICH PLASMA IMPROVES EMBRYO TRANSFER FEASIBILITY AND PREGNANCY OUTCOMES IN PATIENTS WITH POOR ENDOMETRIAL DEVELOPMENT KEY FINDINGS AND CONCLUSIONS: Prior to PRP, 2 of 9 patients (22%) proceeded to embryo transfer; following subendometrial PRP administered at hysteroscopy, 7 of 9 patients (78%) underwent transfer.

Among the seven post-PRP transfers, three patients (43%) achieved a positive pregnancy test, resulting in two ongoing pregnancies and one miscarriage.

The abstract concludes that subendometrial PRP may improve the likelihood of proceeding to embryo transfer and may be associated with favorable pregnancy outcomes in patients with poor endometrial receptivity, supporting further evaluation in larger, prospective studies.

SUBENDOMETRIAL PLATELET-RICH PLASMA AT TIME OF HYSTEROSCOPY IMPROVES ENDOMETRIAL THICKNESS AND CAVITY CHARACTERISTICS IN PATIENTS WITH THIN LINING KEY FINDINGS AND CONCLUSIONS: Endometrial thickness improved in 8 of 9 patients (89%), with mean thickness increasing from 6.1 mm before PRP to 8.1 mm after PRP.

All patients demonstrated a trilaminar endometrial pattern following treatment, compared with 4 of 9 beforehand, and intrauterine fluid present in two patients resolved in both cases.

The abstract concludes that subendometrial PRP administered during hysteroscopy is associated with improved endometrial thickness, restoration of a trilaminar pattern, and resolution of intrauterine fluid, and may be a useful adjunct for patients with thin lining or intrauterine pathology.